(S)-tert-Butyl (1-(3-aminopyridin-4-yl)piperidin-3-yl)carbamate → HCID 51002151, compound

HRID 2088436Notes

Reaction equation

HRID 2088436 reaction equation
C(OC([NH:8][C:9]1[S:13][C:12]([C:14]([CH3:16])=[CH2:15])=[N:11][C:10]=1[C:17]([OH:19])=O)=O)(C)(C)C.[NH2:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][C:26]=1[N:27]1[CH2:32][CH2:31][CH2:30][C@H:29]([NH:33]C(=O)OC(C)(C)C)[CH2:28]1>>[NH2:8][C:9]1[S:13][C:12]([C:14]([CH3:16])=[CH2:15])=[N:11][C:10]=1[C:17]([NH:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][C:26]=1[N:27]1[CH2:32][CH2:31][CH2:30][C@H:29]([NH2:33])[CH2:28]1)=[O:19]

Participants

3

Reactant 2

HCID 59332360(S)-tert-Butyl (1-(3-aminopyridin-4-yl)piperidin-3-yl)carbamateHCID 69810927HCID 69810927, compound

Product 1

HCID 51002151HCID 51002151, compound

Procedure

Followed the procedure as described in EXAMPLE 1, starting with 5-(tert-butoxycarbonylamino)-2-(prop-1-en-2-yl)thiazole-4-carboxylic acid and (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate. Obtained the desired product as a white solid (9 mg). ESIMS m/z=359.3 (M+1).

Sources & evidence

ORD record
ord-ee73b5cc1ed44a5fb41d9ad5bbdfb0ca
Source dataset
uspto-grants-2013_05
Patent number
US08435976B2

Reaction notes

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