Urea → HCID 66955131, compound

Participants

Reaction Steps

4-(4-Fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester was prepared using the Biginelli reaction following the procedure reported in WO 2007/101213). Briefly, to a solution of p-fluorobenzaldehyde (7.5 mL) in 200 mL acetonitrile was added ethyl 3-ethoxyacrylate (10.7 mL), urea (5.0 g) and freshly dried SiO2—NaHSO4 (3.7 g). The solution was heated at reflux for 18 hours, then cooled and poured into ice water. The precipitate was recovered by filtration and air-dried to yield 4-(4-fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (18.8 g).

Provenance & Evidence