Methyl iodide → HCID 58128634, compound

Participants

Reaction Steps

4-(4-Fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (6 g, from Preparation 1), CsCO3 (7.5 g) was added to 50 mL of DMF, followed by CH3I (1.5 mL). The mixture was heated at 60° for 18 hours, then cooled to room temperature and poured into ice water. The resulting precipitate was recovered by filtration and air-dried to give 5.6 g of 4-(4-fluoro-phenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester.

Provenance & Evidence