HCID 86650583, compound → HCID 70794723, compound

Participants

Reaction Steps

The (S)-4-(4-Fluoro-phenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-amide from step 1 was dissolved in a mixture of 1 ml THF, 1 mL water, and 3 ml HOAc. This solution was stirred at room temperature for 18 hours, then diluted with water and extracted with ethyl acetate. The combined ethyl acetate layers were dried over Na2SO4, filtered and the solvent removed in vacuo. The residue was chromatographed in 3% MeOH/CH2Cl2 to give 50 mg of (S)-4-(4-Fluoro-phenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid[4-chloro-5-(2-hydroxy-ethoxy)-2-methyl-phenyl]-amide, MS (M+H)=434.

Provenance & Evidence