Pyridine → HCID 70794788, compound

Participants

Reaction Steps

(S)-4-(4-Fluoro-phenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid chloride, (230 mg), prepared as in Example 1, was added to a solution of 163 mg of 2-methyl-5-(4-methyl-pyrazol-1-yl)-phenylamine, 10 mL propionitrile, and 0.1 mL pyridine. The resulting solution was heated at 100° for 30 minutes, then cooled to 50° and diluted with 5 mL water and 10 mL toluene. The mixture was vigorously stirred at 50° and the layers were separated. The warm toluene layer was washed with saturated sodium bicarbonate, and then concentrated under reduced pressure to a brown residue, which was triturated with 2 mL toluene and filtered. The resulting solid was recrystallized from ethanol/water to yield 175 mg of (S)-4-(4-fluoro-phenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid[2-methyl-5-(4-methyl-pyrazol-1-yl)-phenyl]-amide, MS (M+H)=420.

Provenance & Evidence