Acetic Anhydride → HCID 57441917, compound

HRID 2088484Notes

Reaction equation

HRID 2088484 reaction equation
[CH3:1][C@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[N:9]=[C:10]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][C@@H:26]2[CH3:31])[C:11]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([NH2:24])[CH:19]=3)=[N:14][C:12]=2[N:13]=1.[C:32](OC(=O)C)(=[O:34])[CH3:33]>N1C=CC=CC=1>[CH3:1][C@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[N:9]=[C:10]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][C@@H:26]2[CH3:31])[C:11]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([NH:24][C:32](=[O:34])[CH3:33])[CH:19]=3)=[N:14][C:12]=2[N:13]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 57441908HCID 57441908, compound

Product 1

HCID 57441917HCID 57441917, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
70 °C

Procedure

To a 0.1 M solution of 4-[2,4-bis-((S)-3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-pyridin-2-ylamine (example 1cz) (1 equiv) in pyridine was added acetic anhydride (3 equiv). A reflux condenser was attached to the reaction vessel which was then heated to 70° C. for 2 days. Upon completion, the reaction was purified, in its crude for by preparative HPLC to give the title compound as a white solid.

Workup

  1. customA reflux condenser was attached to the reaction vessel which
  2. customUpon completion, the reaction was purified, in its crude for by preparative HPLC

Sources & evidence

ORD record
ord-04126960358d470c8135b91af855303b
Source dataset
uspto-grants-2013_05
Patent number
US08435985B2

Reaction notes

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