HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 86635024, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl{2-[(4-amino-5-cyano-1,3-thiazol-2-yl)amino]ethyl}carbamate | HCID 57911749 | — |
| Reactant | 6-[(2-Aminoethyl)amino]nicotinonitrile dihydrochloride | HCID 66911329 | — |
| Product | HCID 86635024 | HCID 86635024 | — |
Reaction Steps
Analogously to the preparation of the cyanopyridine (Example 2A), 130 mg (0.46 mmol) of the Boc-protected amine (Example 15A) and 1.05 g (9.18 mmol) of trifluoroacetic acid gave, after removal of all volatile components, 130 mg (96% of theory) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436003B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-3c8aecd226564e518947a3dfdd5e74a0 |
| Source note | uspto-grants-2013_05 |