HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Nitro-N6-(piperidin-3-yl)pyridine-2,6-diamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate | HCID 57911762 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Nitro-N6-(piperidin-3-yl)pyridine-2,6-diamine hydrochloride | HCID 68987419 | — |
Reaction Steps
610 mg (1.62 mmol) of tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate (Example 28A) were dissolved in 40 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 30 min. After the reaction had gone to completion, the solvent was removed completely. This gave 662 mg of the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436003B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e734909f51104d439f6bfb376bea6b70 |
| Source note | uspto-grants-2013_05 |