Water → HCID 178424864, compound

Participants

Reaction Steps

A mixture of Example 1B (1.668 g, 8.41 mmol), guanidine nitrate (2.054 g, 16.83 mmol), and potassium carbonate (2.326 g, 16.83 mmol) was heated in DMF (17 mL) at 120° C. overnight. After this time, the mixture was cooled to room temperature and poured into water. The liquid was adjusted to pH 5 with HOAc, then the precipitate was collected by filtration, washed with water, and air-dried. It was further dried by azeotroping with toluene to yield the title compound. 1H NMR (300 MHz, DMSO-d6) δ 10.59 (br, 1H), 6.02 (br, 2H), 2.57 (m, 2H), 1.48-1.71 (m, 6H), 1.19 (s, 6H). MS (DCI+) m/z 208 (M+H)+.

Provenance & Evidence