HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Amino-phenylmethanesulfonyl)-ethanol → 2-{3-[4-(2-Methoxy-phenyl)-pyrimidin-2-ylamino]-phenylmethanesulfonyl}-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Amino-phenylmethanesulfonyl)-ethanol | HCID 15346010 | — |
| Reactant | 2-Chloro-4-(2-methoxyphenyl)pyrimidine | HCID 24901882 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-{3-[4-(2-Methoxy-phenyl)-pyrimidin-2-ylamino]-phenylmethanesulfonyl}-ethanol | HCID 25101735 | 75.1% |
Reaction Steps
A solution of 2-(3-amino-phenylmethanesulfonyl)-ethanol (0.215 g, 1 mmol) and 2-chloro-4-(2-methoxy-phenyl)-pyrimidine (0.22 g, 1 mmol) in DMF (3 mL) was stirred for 2 hours at 80° C. (TLC control). The solvent was removed under reduced pressure to afford an oily residue which was crystallized from isopropanol yielding 2-{3-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenylmethanesulfonyl}-ethanol (0.3 g, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436007B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-0977b85a8d284556bdb56f32f68ff942 |
| Source note | uspto-grants-2013_05 |