Acetone → HCID 58289927, compound

HRID 2088732Notes

Reaction equation

HRID 2088732 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8]3(CC3)[CH2:9][NH:10][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].C=O.[CH3:18][C:19]([CH3:21])=O>>[CH:19]([N:10]1[CH2:9][CH2:8][C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[CH2:11]1)([CH3:21])[CH3:18]

Participants

4

Reactant 3

HCID 180AcetoneHCID 712FormaldehydeHCID 594706247'-Nitro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]

Product 1

HCID 58289927HCID 58289927, compound

Procedure

870 mg of the entitled compound was obtained as a colorless solid according to the same method as in Production Example 10-6), for which, however, the compound obtained in Production Example 22-1) was used in place of 7′-nitro-1′,2′-dihydro-3′H-spiro[cyclopropane-1,4′-isoquinoline] used in Production Example 10-6), and acetone was used in place of aqueous formaldehyde solution.

Workup

  1. customhowever, the compound obtained in Production Example 22-1)

Sources & evidence

ORD record
ord-da8ea0931dd945c3b33a0f1b585ab67d
Source dataset
uspto-grants-2013_05
Patent number
US08436004B2

Reaction notes

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