Acetone → HCID 10899183, compound

Participants

Reaction Steps

A polyphosphoric acid (200 g) solution of 10 g of phenylacetonitrile was heated at 140° C., and 14.9 g of acetone was dropwise added thereto, taking 1 hour. Further, this was stirred for 1 hour, then cooled, and ice water and diisopropyl ether were added to the reaction liquid. The organic layer was separated, and the aqueous layer was extracted with chloroform. The chloroform layer was washed with aqueous saturated sodium hydrogencarbonate solution, dried with anhydrous magnesium sulfate, and the solvent was evaporated away to obtain 6.22 g of the entitled compound as a brown solid.

Provenance & Evidence