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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2088736Generated: October 27, 2026

6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine → (6S*)-6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine

https://huagongshe.com/reaction/2088736

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amineHCID 21939721—
ReactantHexane isopropanol diethylamineHCID 21973129—
Product(6S*)-6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amineHCID 58289871—
Product(6R*)-6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amineHCID 58289880—

Reaction Steps

6-[(Dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine was optically resolved, using CHIRALCEL OD-H (20 mm×250 mm) (hexane/isopropanol/diethylamine=75/25/0.1) to obtain 156 mg of (6R*)-6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine, and 159 mg of (6S*)-6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08436004B2
Source datasetuspto-grants-2013_05
ORD IDord-fcb157dc33884b199e82bfa201aa4624
Source noteuspto-grants-2013_05