Potassium Phosphate, Tribasic → HCID 67222847, compound

Participants

Reaction Conditions

Reaction Steps

5 mL of 1,4-dioxane was added to 552 mg of 6-bromo-3,4-dihydroisoquinolin-1(2H)-one, 0.521 mL of 2-iodopyridine, 0.077 mL of trans-N,N′-dimethylcyclohexane-1,2-diamine and 622 mg of tripotassium phosphate, and stirred at 100° C. for 2 hours. Ethyl acetate was added to the reaction liquid, washed with aqueous saturated ammonia solution and saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the residue was purified through silica gel column chromatography (hexane/ethyl acetate) to obtain 582 mg of a mixture (1/1) of the entitled compound with 6-iodo-2-pyridin-2-yl-3,4-dihydroisoquinolin-1(2H)-one as a white solid.

Provenance & Evidence