Sulfuric Acid → HCID 58290020, compound

HRID 2088742Notes

Reaction equation

HRID 2088742 reaction equation
[N+:1]([O-:4])([O-])=[O:2].[K+].S(=O)(=O)(O)O.[CH3:11][C:12]1([CH3:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][C:14](=[O:22])[NH:13]1>>[CH3:11][C:12]1([CH3:23])[C:21]2[C:16](=[CH:17][C:18]([N+:1]([O-:4])=[O:2])=[CH:19][CH:20]=2)[CH2:15][C:14](=[O:22])[NH:13]1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 10899183HCID 10899183, compound

Product 1

HCID 58290020HCID 58290020, compoundYield 74.6%

Procedure

With cooling with ice, 692 mg of potassium nitrate was added to 4 mL of sulfuric acid, and 1 g of 1,1-dimethyl-1,4-dihydroisoquinolin-3(2H)-one obtained in Production Example 33-1 was added thereto, and stirred overnight at room temperature. The reaction solution was processed with ice water, and the precipitated solid was taken out through filtration. This was washed with water, and dried at 50° C. under reduced pressure to obtain 937 mg of a mixture of the entitled compound with its position isomer, as a pale yellow solid.

Workup

  1. customobtained in Production Example 33-1
  2. additionwas added
  3. filtrationthe precipitated solid was taken out through filtration
  4. washThis was washed with water
  5. customdried at 50° C. under reduced pressure

Sources & evidence

ORD record
ord-88d59368fe9f43abac4a8e586dfe5c1c
Source dataset
uspto-grants-2013_05
Patent number
US08436004B2

Reaction notes

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