Sodium Hydroxide → HCID 58289816, compound

Participants

Reaction Conditions

Reaction Steps

29 mg of lithiumaluminium hydride was added to 3.8 mL of a THF solution of 89 mg of 5-amino-2,3,3,-trimethylisoindolin-1-one, and the mixture was stirred at 70° C. for 3 hours. 0.05 mL of aqueous 5 M sodium hydroxide solution was added to it, and the solvent was evaporated away under reduced pressure. 10% methanol/chloroform was added to the residue, the mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified through basic silica gel column chromatography (hexane/ethyl acetate) to obtain 45 mg of the entitled compound as a pale yellow solid.

Provenance & Evidence