2,5-Dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine → HCID 178428292, compound

HRID 2088751Notes

Reaction equation

HRID 2088751 reaction equation
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([NH2:13])=[CH:7][C:8]=2[CH3:12])[CH2:3]1.Cl[C:15]1[N:20]=[C:19]2[NH:21][C:22](=[O:34])[N:23]([C:26]3[C:31]([CH3:32])=[CH:30][CH:29]=[CH:28][C:27]=3[Cl:33])[C:24](=[NH:25])[C:18]2=[CH:17][N:16]=1.ClC1N=C2NC(=O)N(C3C(Cl)=CC=CC=3Cl)C(=N)C2=CN=1>>[Cl:33][C:27]1[CH:28]=[CH:29][CH:30]=[C:31]([CH3:32])[C:26]=1[N:23]1[C:24](=[NH:25])[C:18]2[C:19](=[N:20][C:15]([NH:13][C:6]3[CH:5]=[C:4]4[C:9]([CH2:10][CH2:11][N:2]([CH3:1])[CH2:3]4)=[C:8]([CH3:12])[CH:7]=3)=[N:16][CH:17]=2)[NH:21][C:22]1=[O:34]

Participants

4

Reactant 3

HCID 672241762,5-Dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amineHCID 178425044HCID 178425044, compoundHCID 178507161HCID 178507161, compound

Product 1

HCID 178428292HCID 178428292, compound

Procedure

7 mg of the entitled compound was obtained as a white solid according to the same method as in Example 2, for which, however, 2,5-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2-chloro-6-methylphenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 2 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one.

Workup

  1. customobtained in Production Example 2

Sources & evidence

ORD record
ord-e89d8279e0784c7fa4d6cc1d29d31acf
Source dataset
uspto-grants-2013_05
Patent number
US08436004B2

Reaction notes

Loading…