Thiophene → HCID 58625066, compound

HRID 2088781Notes

Reaction equation

HRID 2088781 reaction equation
[N+:1]([C:4]1[CH:26]=[CH:25][C:7]([O:8][C:9]2[CH:10]=[C:11]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)=[CH:6][C:5]=1[CH2:27][NH:28][CH2:29][CH2:30][CH3:31])([O-])=O.S1C=CC=C1.O=[Si]=O>CO.[Pd]>[NH2:1][C:4]1[CH:26]=[CH:25][C:7]([O:8][C:9]2[CH:10]=[C:11]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=2)=[CH:6][C:5]=1[CH2:27][NH:28][CH2:29][CH2:30][CH3:31]

Participants

6

Reactant 3

HCID 8030ThiopheneHCID 24261SilicaHCID 58625170HCID 58625170, compound

Product 1

HCID 58625066HCID 58625066, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of N-[3-(4-nitro-3-propylaminomethyl-phenoxy)-phenyl]-benzenesulfonamide (0.0045 mol) in methanol (100 mL) was hydrogenated with 10% Pd/C (0.5 g) as a catalyst in the presence of thiophene solution (1 mL). After uptake of H2 gas (3 equiv.), the reaction mixture was filtered over Dicalite and the filtrate was evaporated to yield the title compound as a residue.

Workup

  1. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-45b61082c6a24e08b11a115ac4b1d3e2
Source dataset
uspto-grants-2013_05
Patent number
US08436006B2

Reaction notes

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