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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2088790Generated: November 2, 2026

HCID 58625150, compound → 3-Propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-ylamine

https://huagongshe.com/reaction/2088790

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 58625150HCID 58625150—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
Product3-Propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-ylamineHCID 58625049—

Reaction Steps

A mixture of (3-propyl-6-{3-[(2,4,6-trimethyl-benzylamino)-methyl]-phenoxy}-3,4-dihydro-quinazolin-2-yl)-carbamic acid tert-butyl ester (0.00041 mol) in trifluoroacetic acid (1 mL) and DCM (10 mL) was stirred overnight at room temperature and the solvent was evaporated. The obtained residue was decomposed in diisopropyl ether/CH3CN, then the desired product was filtered off and dried to yield the title compound as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08436006B2
Source datasetuspto-grants-2013_05
ORD IDord-566bd9da1fb441559532ad92aa0d3f5d
Source noteuspto-grants-2013_05