Ammonium Hydroxide → HCID 86666564, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve methyl 3-(4,6-dichloropyrimidin-5-yl)pentanoate (10.00 g, 38.01 mmol) in 28% ammonium hydroxide in water (95 mL) and seal in a 350 mL tube. Heat the reaction mixture to 200° C. for 2 hours. Cool the reaction mixture in an ice bath, then filter and wash with cold water. Dry the solids under vacuum to give the racemate. Chiral separation (Chiralpak AS-H, 100% ethanol w/0.2% dimethyl ethylamine) provides the title compound as enantiomer 2 (3.19 g, 40%) (>99% ee). MS (ES) m/z=212 [M]+.

Provenance & Evidence