Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 5,5,5-Trifluoropentanal | HCID 22915404 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86666571 | HCID 86666571 | 100% |
Reaction Steps
Combine 5,5,5-trifluoropentanal (2.01 g, 14.35 mmol), 1,4-dioxane (10 mL), selenium dioxide (1.62 g, 1.0 eq), water (0.51 mL), and acetic acid (0.69 mL). Heat the mixture at 90° C. and stir overnight. Allow the reaction mixture to cool to room temperature. Filter, wash the solids with dioxane. Combine the filtrate and washings to give the title compound (2.21 g, 100%). GCMS m/z=154.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08436002B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-21fe0221566c40b28b78b2239fb790ff |
|---|
| Source note | uspto-grants-2013_05 |
|---|
