Potassium Hydroxide → HCID 67954505, compound

Participants

Reaction Conditions

Reaction Steps

Combine tert-butyl 4-(4-isobutyl-1H-imidazol-2-yl)piperidine-1-carboxylate (1.50 g, 4.88 mmol) and potassium hydroxide (1.65 g, 6.0 eq) (freshly powdered) in dimethyl sulfoxide (30 mL). Heat the reaction mixture to 45° C. under nitrogen. After 5 minutes, add 1-(2-chloroethyl)pyrrolidine hydrochloride (1.08 g, 1.3 eq). Stop heating after 2 hours. Add water and extract with ethyl acetate. Dry the organics over anhydrous magnesium sulfate, filter, and concentrate in vacuo to give the title compound as a yellow oil (2.11 g, 100%). MS (ES) m/z=405 [M]+.

Provenance & Evidence