Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 22915404 | HCID 22915404 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86666571 | HCID 86666571 | 100% |
Reaction Steps
Combine 5,5,5-trifluoropentanal (2.01 g, 14.35 mmol), 1,4-dioxane (10 mL), selenium dioxide (1.62 g, 1.0 eq), water (0.51 mL), and acetic acid (0.69 mL). Heat the mixture at 90° C. and stir overnight. Allow the reaction mixture to cool to room temperature. Filter, wash the solids with dioxane. Combine the filtrate and washings to give 5,5,5-trifluoro-2-oxopentanal (2.21 g, 100%). GCMS m/z=154.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08436002B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-728d634008cf49d99da9c503217a1a30 |
|---|
| Source note | uspto-grants-2013_05 |
|---|
