HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2088934Generated: November 1, 2026
Trifluoroacetic acid → HCID 86666583, compound
https://huagongshe.com/reaction/2088934
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 4-(1-(2-(pyrrolidin-1-yl)ethyl)-4-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl)piperidine-1-carboxylate | HCID 67112062 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86666583 | HCID 86666583 | 100% |
Reaction Steps
Combine tert-butyl 4-(1-(2-(pyrrolidin-1-yl)ethyl)-4-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (0.73 g, 1.64 mmol) and dichloromethane (16.2 mL). Place under nitrogen and cool to 0° C. Add trifluoroacetic acid (16.2 mL). After 1 hour, concentrate in vacuo to give 4-(4-(3,3,3-trifluoropropyl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine tris(2,2,2-trifluoroacetate) (1.12 g, 100%). MS (ES) m/z=345 [M]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08436002B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-5c35bc4a7959461ea5b1a6953da6478c |
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| Source note | uspto-grants-2013_05 |
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