HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 5-bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine | HCID 40152257 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Bromo-3-chloro-4-methyl-1H-pyrrolo[2,3-b]pyridine | HCID 53412933 | 96.9% |
Reaction Steps
The compound obtained in Step 3 of Example 36 (323 mg) was dissolved in tetrahydrofuran (6 ml). N-Chlorosuccinimide (225 mg) was added and the mixture was stirred at room temperature for three days. Water was added to the reaction solution, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to give the title compound (364 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436012B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-58a52b4aa75a439eba2f2414f9bf642e |
| Source note | uspto-grants-2013_05 |