反应详情

A mixture of Example 61a (3.4 g) in acetonitrile (30 mL) and trans-cyclohexane-1,2-diamine was heated at 170° C. for 40 minutes in a Biotage microwave reactor. The reaction mixture was extracted with ethyl acetate (2×), washed with brine and sodium bicarbonate. The combined organic layers were treated with 1M HCl. The aqueous layer was treated with NaOH (1M) and the material crashed out of the solution to give 0.797 mg of the title compound.

1. extractionThe reaction mixture was extracted with ethyl acetate (2×)
2. washwashed with brine and sodium bicarbonate
3. additionThe combined organic layers were treated with 1M HCl
4. additionThe aqueous layer was treated with NaOH (1M)