Trifluoroacetic acid → HCID 87191603, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 150a (0.500 g, 0.990 mmol) in CH2Cl2 (9 mL) was added trifluoroacetic acid (4 mL, 51.9 mmol). The mixture was heated at 35° C. for 6 hours and concentrated. The residue was treated with saturated NaHCO3 and extracted with EtOAc. The organic layer was concentrated. The crude was triturated with EtOAc/diethyl ether to give 222 mg of the title compound. The filtrate was concentrated and purified on a 12 g column using the ISCO Companion flash system eluting with CH2Cl2/EtOAc (95:5 to 90:10) to give more title compound (84 mg).

Provenance & Evidence