Ethyl isocyanate → HCID 66887804, compound

Participants

Reaction Steps

To a suspension of Example 226a (120 mg, 0.234 mmol) in 5 mL dichloromethane was added triethylamine (0.326 mL, 2.34 mmol) followed by addition of ethyl isocyanate (0.074 mL, 0.935 mmol). The reaction mixture was stirred 16 hours at room temperature and then concentrated to dryness. The residue was partitioned with sodium bicarbonate solution and ethyl acetate. The organics were concentrated to dryness and the residue purified by silica gel flash chromatography eluting with 15% ethyl acetate, 85% dichloromethane to give the title compound as a pink-brown powder in quantitative yield. MS (ESI+) m/z 471.0 (M+H)+.

Provenance & Evidence