HCID 66886812, compound → HCID 86649872, compound

Participants

Reaction Steps

To a suspension of Example 226a (118 mg, 0.23 mmol) in 4 mL dichloromethane was added triethylamine (0.64 mL, 4.6 mmol). The reaction flask was cooled in an ice bath and methanesulfonyl chloride (0.054 mL, 0.69 mmol) added. After stirring 10 minutes, the ice bath was removed and the reaction mixture stirred 2 days at room temperature. The solvent was evaporated to dryness to give a crude product that was a mixture of N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl)methanesulfonamide and N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl)-N-(methylsulfonyl)methansulfonamide that was carried on to the next step without purification.

Provenance & Evidence