Sodium Hydroxide → HCID 87191648, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 260c (0.083 g, 0.135 mmol) in dioxane (2 mL) was treated with 20% NaOH (0.08 mL, 0.135 mmol). The mixture was heated at 70° C. for 90 minutes. The solvent was evaporated. The residue was treated with water and sonicated. The solid was filtered, washed with water, and purified by reverse-phase HPLC as described in Example 56 to give the title compound (43.2 mg) as trifluoroacetic acid salts. 1H NMR (400 MHz, DMSO-d6) ppm 0.83-0.98 (m, 4H), 0.98-1.26 (m, 3H), 1.38 (m, 1H), 1.74 (m, 1H), 1.86-1.98 (m, 2H), 2.31 (d, J=13.43 Hz, 1H), 2.56 (m, 1H), 3.24 (m, 1H, 3.73 (m, 1H), 3.90 (s, 3H), 6.81 (s, 1H), 6.88 (d, J=1.22 Hz, 1H), 7.14 (d, J=8.24 Hz, 1H), 7.79 (d, J=2.75 Hz, 1H), 8.09 (dd, J=7.93, 2.75 Hz, 2H), 12.04 (s, 1H). MS (ESI+) m/z 476.2 (M+H)+.

Provenance & Evidence