HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 8-Benzyloxy-3-methyl-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Methyl-quinolin-2,8-diol | HCID 440986 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-Benzyloxy-3-methyl-1H-quinolin-2-one | HCID 22499223 | — |
Reaction Steps
Benzyl bromide (1.28 mL) is added to a suspension of potassium carbonate (2.98 g) in a solution of 8-hydroxy-3-methyl-1H-quinolin-2-one (1.26 g) in acetone (36 mL) at room temperature. The reaction mixture is refluxed for 18 hours, filtered, evaporated and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436017B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-66f0db45898e49b692cb26673b34f593 |
| Source note | uspto-grants-2013_05 |