(1,1'-Bicyclohexyl)-4-one → N-(1-Bicyclohexyl-4-yl-azetidin-3-yl)-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

HRID 2089136Notes

Reaction equation

HRID 2089136 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1.[CH:30]1([CH:37]2[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]2)[CH2:35][CH2:34][C:33](=O)[CH2:32][CH2:31]1>>[CH:30]1([CH:37]2[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]2)[CH2:35][CH2:34][CH:33]([N:8]2[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]3[C:20]4[CH:21]=[C:22]([C:25]([F:27])([F:26])[F:28])[CH:23]=[CH:24][C:19]=4[O:18][N:17]=3)[CH2:9]2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 41690(1,1'-Bicyclohexyl)-4-oneHCID 86660176N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt

Product 1

HCID 54756037N-(1-Bicyclohexyl-4-yl-azetidin-3-yl)-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

Procedure

The title compound was prepared as a white solid from reaction of (N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt (as prepared in Example 1, Step D) and bicyclohexyl-4-one using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-7359ec203fda4409a3a7ce220297279e
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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