HRID2089141

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1512535

tert-butyl N-(4-oxocyclohexyl)carbamate

C11H19NO3

反应SMILES：O=C(CNc1noc2ccc(C(F)(F)F)cc12)NC1CNC1.O=C(O)C(F)(F)F

HCID86660176

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)OC(=O)NC1CCC(N2CC(NC(=O)CNc3noc4ccc(C(F)(F)F)cc34)C2)CC1

HCID67478837

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of (N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt (as prepared in Example 1, Step D) and (4-oxo-cyclohexyl)-carbamic acid tert-butyl ester using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-648c8f7f28c040158330c091d387ec6f
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08436023B2
来源说明: uspto-grants-2013_05

反应SMILES

OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1.[C:30]([O:34][C:35](=[O:44])[NH:36][CH:37]1[CH2:42][CH2:41][C:40](=O)[CH2:39][CH2:38]1)([CH3:33])([CH3:32])[CH3:31]>>[C:30]([O:34][C:35](=[O:44])[NH:36][CH:37]1[CH2:38][CH2:39][CH:40]([N:8]2[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]3[C:20]4[CH:21]=[C:22]([C:25]([F:27])([F:26])[F:28])[CH:23]=[CH:24][C:19]=4[O:18][N:17]=3)[CH2:9]2)[CH2:41][CH2:42]1)([CH3:33])([CH3:31])[CH3:32]