4-Isopropylcyclohexanone → N-[1-(4-Isopropyl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethoxy-benzo[d]isoxazol-3-ylamino)-acetamide
Reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:30])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([O:25][C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1.[CH:31]([CH:34]1[CH2:39][CH2:38][C:37](=O)[CH2:36][CH2:35]1)([CH3:33])[CH3:32]>>[CH:31]([CH:34]1[CH2:39][CH2:38][CH:37]([N:8]2[CH2:9][CH:10]([NH:12][C:13](=[O:30])[CH2:14][NH:15][C:16]3[C:20]4[CH:21]=[C:22]([O:25][C:26]([F:28])([F:27])[F:29])[CH:23]=[CH:24][C:19]=4[O:18][N:17]=3)[CH2:11]2)[CH2:36][CH2:35]1)([CH3:33])[CH3:32]Participants
3
Procedure
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethoxy-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt (as prepared in Example 1, Step D) and 4-isopropyl-cyclohexanone using the procedure described in Step E of Example 1.
Sources & evidence
- ORD record
- ord-01702095413b4e92bd991768943356a7
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08436023B2
Reaction notes
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