HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 3-[2-(1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Tert-butyl 3-aminoazetidine-1-carboxylate | HCID 1516507 | — |
| Reactant | (1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid | HCID 67478753 | — |
| Product | 3-[2-(1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester | HCID 67479124 | — |
Reaction Steps
The title compound was prepared as white foam from EDCI coupling of (1-methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid (as prepared in the previous step) and 3-amino-azetidine-1-carboxylic acid tert-butyl ester using the procedure described in Step C of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e31ea696cce24aa68c6eca3c84a47c75 |
| Source note | uspto-grants-2013_05 |