HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Ethyl 4-oxocyclohexanecarboxylate | HCID 317638 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate | HCID 10488810 | — |
Reaction Steps
4-Oxo-cyclohexanecarboxylic acid ethyl ester (Aldrich, 6.1 g, 35.8 mmol), ethylene glycol (3.34 g, 53.8 mmol), pTSA (123 mg, 0.717 mmol) in toluene (100 mL) was refluxed in Dean-Stark until no water was observed. The resulting solution was washed with saturated NaHCO3 and brine, dried over anhydrous Na2SO4, filtered and concentrated to give 1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-936bb385892f4f9c8ff6f86fb2c6daa2 |
| Source note | uspto-grants-2013_05 |