4-(Hydroxymethyl)cyclohexan-1-one → HCID 54754722, compound

HRID 2089169Notes

Reaction equation

HRID 2089169 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:30])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([CH3:29])[N:17]=2)[CH2:9]1.[OH:31][CH2:32][CH:33]1[CH2:38][CH2:37][C:36](=O)[CH2:35][CH2:34]1>>[OH:31][CH2:32][CH:33]1[CH2:38][CH2:37][CH:36]([N:8]2[CH2:9][CH:10]([NH:12][C:13](=[O:30])[CH2:14][NH:15][C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:27])([F:26])[F:28])[CH:23]=4)[N:18]([CH3:29])[N:17]=3)[CH2:11]2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 128928674-(Hydroxymethyl)cyclohexan-1-oneHCID 86660178N-Azetidin-3-yl-2-(1-methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt

Product 1

HCID 54754722HCID 54754722, compound

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt (as prepared in Example 18, Step D) and 4-hydroxymethyl-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-880f52b57f544270b5d269eb09bba95f
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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