AGN-PC-0ND25R → N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

HRID 2089183Notes

Reaction equation

HRID 2089183 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.[O:23]1[C:27]2[CH:28]=[CH:29][C:30]([CH:32]3[CH2:37][CH2:36][C:35](=O)[CH2:34][CH2:33]3)=[CH:31][C:26]=2[O:25][CH2:24]1>>[O:23]1[C:27]2[CH:28]=[CH:29][C:30]([CH:32]3[CH2:37][CH2:36][CH:35]([N:1]4[CH2:2][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]5[C:17]6[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=6)[NH:11][N:10]=5)[CH2:4]4)[CH2:34][CH2:33]3)=[CH:31][C:26]=2[O:25][CH2:24]1

Participants

3

Reactant 2

HCID 10932904AGN-PC-0ND25RHCID 58548846HCID 58548846, compound

Product 1

HCID 54754969N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and 4-benzo[1,3]dioxol-5-yl-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-9edb62bcbb964aa890b0f85733048c84
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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