HCID 58548846, compound → N-{1-[4-(6-Methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

HRID 2089184Notes

Reaction equation

HRID 2089184 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.[CH3:23][O:24][C:25]1[N:30]=[CH:29][C:28]([CH:31]2[CH2:36][CH2:35][C:34](=O)[CH2:33][CH2:32]2)=[CH:27][CH:26]=1>>[CH3:23][O:24][C:25]1[N:30]=[CH:29][C:28]([CH:31]2[CH2:32][CH2:33][CH:34]([N:1]3[CH2:2][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]4[C:17]5[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=5)[NH:11][N:10]=4)[CH2:4]3)[CH2:35][CH2:36]2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 58548846HCID 58548846, compoundHCID 674788684-(6-Methoxypyridin-3-yl)cyclohexanone

Product 1

HCID 54754968N-{1-[4-(6-Methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and 4-(6-methoxy-pyridin-3-yl)-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-519ede7171a2499b953ca3c24f8394ad
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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