HRID2089185

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(CNc1n[nH]c2ccc(C(F)(F)F)cc12)NC1CNC1

HCID58548846

未命名化合物

HCID67479087

未命名化合物

PRODUCTS

生成物

结构：NC(=O)Cc1ccc(C2CCC(N3CC(NC(=O)CNc4n[nH]c5ccc(C(F)(F)F)cc45)C3)CC2)cc1

HCID54755079

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and 2-[4-(4-oxo-cyclohexyl)-phenyl]-acetamide using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0b1b89af13954d11ac0fddf3fae35e6b
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.O=[C:24]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:35]=[CH:34][C:33]([CH2:36][C:37]([NH2:39])=[O:38])=[CH:32][CH:31]=2)[CH2:26][CH2:25]1>>[F:21][C:18]([F:20])([F:19])[C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[NH:11][N:10]=[C:9]2[NH:8][CH2:7][C:6]([NH:5][CH:3]1[CH2:2][N:1]([CH:24]2[CH2:25][CH2:26][CH:27]([C:30]3[CH:35]=[CH:34][C:33]([CH2:36][C:37]([NH2:39])=[O:38])=[CH:32][CH:31]=3)[CH2:28][CH2:29]2)[CH2:4]1)=[O:22]