HCID 58548846, compound → 2-[4-(4-{3-[2-(5-Trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-phenyl]-acetamide

HRID 2089185Notes

Reaction equation

HRID 2089185 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.O=[C:24]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:35]=[CH:34][C:33]([CH2:36][C:37]([NH2:39])=[O:38])=[CH:32][CH:31]=2)[CH2:26][CH2:25]1>>[F:21][C:18]([F:20])([F:19])[C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[NH:11][N:10]=[C:9]2[NH:8][CH2:7][C:6]([NH:5][CH:3]1[CH2:2][N:1]([CH:24]2[CH2:25][CH2:26][CH:27]([C:30]3[CH:35]=[CH:34][C:33]([CH2:36][C:37]([NH2:39])=[O:38])=[CH:32][CH:31]=3)[CH2:28][CH2:29]2)[CH2:4]1)=[O:22]

Participants

3

Reactant 2

HCID 58548846HCID 58548846, compoundHCID 674790872-[4-(4-Oxo-cyclohexyl)-phenyl]-acetamide

Product 1

HCID 547550792-[4-(4-{3-[2-(5-Trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-phenyl]-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and 2-[4-(4-oxo-cyclohexyl)-phenyl]-acetamide using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-0b1b89af13954d11ac0fddf3fae35e6b
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

Loading…