Ethyl 4-oxocyclohexanecarboxylate → HCID 54755081, compound

HRID 2089188Notes

Reaction equation

HRID 2089188 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.[CH2:23]([O:25][C:26]([CH:28]1[CH2:33][CH2:32][C:31](=O)[CH2:30][CH2:29]1)=[O:27])[CH3:24]>>[CH2:23]([O:25][C:26]([CH:28]1[CH2:33][CH2:32][CH:31]([N:1]2[CH2:2][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=4)[NH:11][N:10]=3)[CH2:4]2)[CH2:30][CH2:29]1)=[O:27])[CH3:24]

Participants

3

Reactant 2

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 58548846HCID 58548846, compound

Product 1

HCID 54755081HCID 54755081, compound

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and 4-oxo-cyclohexanecarboxylic acid ethyl ester using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-7b99fd5c70e94c0daa738a31a108360c
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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