tert-butyl N-(4-oxocyclohexyl)carbamate → HCID 67478999, compound

HRID 2089189Notes

Reaction equation

HRID 2089189 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.[C:23]([O:27][C:28](=[O:37])[NH:29][CH:30]1[CH2:35][CH2:34][C:33](=O)[CH2:32][CH2:31]1)([CH3:26])([CH3:25])[CH3:24]>>[C:23]([O:27][C:28](=[O:37])[NH:29][CH:30]1[CH2:31][CH2:32][CH:33]([N:1]2[CH2:2][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=4)[NH:11][N:10]=3)[CH2:4]2)[CH2:34][CH2:35]1)([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 1512535tert-butyl N-(4-oxocyclohexyl)carbamateHCID 58548846HCID 58548846, compound

Product 1

HCID 67478999HCID 67478999, compound

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide (as prepared in Example 41, Step A) and (4-oxo-cyclohexyl)-carbamic acid tert-butyl ester using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-d250ad6f82c1407f9a429d3d86534ee2
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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