HCID 58548846, compound → N-{1-[4-(2-Oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

HRID 2089191Notes

Reaction equation

HRID 2089191 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[NH:11][N:10]=2)[CH2:2]1.O=[C:24]1[CH2:29][CH2:28][CH:27]([N:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]2=[O:36])[CH2:26][CH2:25]1>>[O:36]=[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][N:30]1[CH:27]1[CH2:28][CH2:29][CH:24]([N:1]2[CH2:2][CH:3]([NH:5][C:6](=[O:22])[CH2:7][NH:8][C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=4)[NH:11][N:10]=3)[CH2:4]2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 58548846HCID 58548846, compoundHCID 585626631-(4-Oxo-cyclohexyl)-1H-pyridin-2-one

Product 1

HCID 54755083N-{1-[4-(2-Oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide and 1-(4-oxo-cyclohexyl)-1H-pyridin-2-one using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-8221c7639d174949b1d0e11cc957adaf
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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