HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-oxocyclohexanecarboxylate → 4-(3-{2-[1-Methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetylamino}-azetidin-1-yl)-cyclohexanecarboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-oxocyclohexanecarboxylate | HCID 317638 | — |
| Reactant | N-azetidin-3-yl-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide TFA salt | HCID 86660179 | — |
| Product | 4-(3-{2-[1-Methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetylamino}-azetidin-1-yl)-cyclohexanecarboxylic acid ethyl ester | HCID 54755313 | — |
Reaction Steps
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-[1-methyl-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-1H-indazol-3-ylamino]-acetamide TFA salt (as prepared in the previous step) and 4-oxo-cyclohexanecarboxylic acid ethyl ester using the procedure described in Step E of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-648ef3a0fd9e45dfa8afc9ad2b6da827 |
| Source note | uspto-grants-2013_05 |