(Diethylamino)sulfur trifluoride → HCID 67478733, compound

Participants

Reaction Steps

2-Fluoro-5-(2,2,2-trifluoro-1-hydroxy-ethyl)-benzonitrile (1 g, 4.56 mmol) in DCM (5 mL) was treated with DAST (Aldrich, 1.12 mL, 9.13 mmol) at −78° C. for 2 hours. The reaction was quenched with saturated NaHCO3 and extracted with DCM. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated to give the crude material, purified by silica gel column (hexanes:ethyl acetate 4:1) to afford the title compound as colorless solid (1.01 g, 100%).

Provenance & Evidence