HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-4-(thiazol-5-yl)cyclohexanone → 2-(1-Ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-[1-(4-hydroxy-4-thiazol-5-yl-cyclohexyl)-azetidin-3-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-4-(thiazol-5-yl)cyclohexanone | HCID 59017439 | — |
| Reactant | N-azetidin-3-yl-2-(1-ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt | HCID 86660181 | — |
| Product | 2-(1-Ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-[1-(4-hydroxy-4-thiazol-5-yl-cyclohexyl)-azetidin-3-yl]-acetamide | HCID 54755434 | — |
Reaction Steps
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt (as prepared in the previous step) and 4-hydroxy-4-thiazol-5-yl-cyclohexanone using the procedure described in Step E of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-54860a6e787c4ec9adff34403f66ec02 |
| Source note | uspto-grants-2013_05 |