4-Isopropylcyclohexanone → 2-(1-Ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-[1-(4-isopropyl-cyclohexyl)-azetidin-3-yl]-acetamide
Reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:31])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([CH2:29][CH3:30])[N:17]=2)[CH2:9]1.[CH:32]([CH:35]1[CH2:40][CH2:39][C:38](=O)[CH2:37][CH2:36]1)([CH3:34])[CH3:33]>>[CH2:29]([N:18]1[C:19]2[C:24](=[CH:23][C:22]([C:25]([F:27])([F:26])[F:28])=[CH:21][CH:20]=2)[C:16]([NH:15][CH2:14][C:13]([NH:12][CH:10]2[CH2:9][N:8]([CH:38]3[CH2:39][CH2:40][CH:35]([CH:32]([CH3:34])[CH3:33])[CH2:36][CH2:37]3)[CH2:11]2)=[O:31])=[N:17]1)[CH3:30]Participants
3
Procedure
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-ethyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt (as prepared in Example 67, Step A) and 4-isopropyl-cyclohexanone using the procedure described in Step E of Example 1.
Sources & evidence
- ORD record
- ord-0fd644001854485582185f5730446496
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08436023B2
Reaction notes
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