Ethyl 4-oxocyclohexanecarboxylate → HCID 54755562, compound

HRID 2089206Notes

Reaction equation

HRID 2089206 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:34])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([CH2:29][C:30]([F:33])([F:32])[F:31])[N:17]=2)[CH2:9]1.[CH2:35]([O:37][C:38]([CH:40]1[CH2:45][CH2:44][C:43](=O)[CH2:42][CH2:41]1)=[O:39])[CH3:36]>>[CH2:35]([O:37][C:38]([CH:40]1[CH2:45][CH2:44][CH:43]([N:8]2[CH2:11][CH:10]([NH:12][C:13](=[O:34])[CH2:14][NH:15][C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:27])([F:28])[F:26])[CH:23]=4)[N:18]([CH2:29][C:30]([F:31])([F:32])[F:33])[N:17]=3)[CH2:9]2)[CH2:42][CH2:41]1)=[O:39])[CH3:36]

Participants

3

Reactant 2

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 86660182N-(azetidin-3-yl)-2-((1-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)-1H-indazol-3-yl)amino)acetamide TFA salt

Product 1

HCID 54755562HCID 54755562, compound

Procedure

The title compound was prepared as a white solid from reaction of N-(azetidin-3-yl)-2-((1-(2,2,2-trifluoroethyl)-5-(trifluoromethyl)-1H-indazol-3-yl)amino)acetamide TFA salt (as prepared in the previous step) and 4-oxo-cyclohexanecarboxylic acid ethyl ester using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-c6d9fea33b644d6b91999ad7507fa49c
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

Loading…