HRID2089209

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID52987995

4-Hydroxy-4-(6-methoxypyridin-3-yl)cyclohexan-1-one

C12H15NO3

结构：O=C(CNc1nn(CCO)c2ccc(C(F)(F)F)cc12)NC1CNC1.O=C(O)C(F)(F)F

HCID86660184

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2(O)CCC(N3CC(NC(=O)CNc4nn(CCO)c5ccc(C(F)(F)F)cc45)C3)CC2)cn1

HCID54755679

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-[1-(2-hydroxy-ethyl)-5-trifluoromethyl-1H-indazol-3-ylamino]-acetamide TFA salt (as prepared in Example 74, Step A) and 4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone using the procedure described in Step E of Example 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd34dd02079143bf8b2feec12af4b223
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436023B2
来源说明: uspto-grants-2013_05

反应 SMILES

OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:32])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([CH2:29][CH2:30][OH:31])[N:17]=2)[CH2:9]1.[OH:33][C:34]1([C:41]2[CH:42]=[N:43][C:44]([O:47][CH3:48])=[CH:45][CH:46]=2)[CH2:39][CH2:38][C:37](=O)[CH2:36][CH2:35]1>>[OH:31][CH2:30][CH2:29][N:18]1[C:19]2[C:24](=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)[C:16]([NH:15][CH2:14][C:13]([NH:12][CH:10]2[CH2:11][N:8]([CH:37]3[CH2:36][CH2:35][C:34]([OH:33])([C:41]4[CH:42]=[N:43][C:44]([O:47][CH3:48])=[CH:45][CH:46]=4)[CH2:39][CH2:38]3)[CH2:9]2)=[O:32])=[N:17]1