4-Oxocyclohexane-1-carbonitrile → HCID 54755925, compound

HRID 2089222Notes

Reaction equation

HRID 2089222 reaction equation
OC(C(F)(F)F)=O.[C:8]([NH:12][C:13]([N:15]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=2)[C:17]([NH:28][CH2:29][C:30](=[O:36])[NH:31][CH:32]2[CH2:35][NH:34][CH2:33]2)=[N:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9].[C:37]([CH:39]1[CH2:44][CH2:43][C:42](=O)[CH2:41][CH2:40]1)#[N:38]>>[C:8]([NH:12][C:13]([N:15]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([F:26])([F:25])[F:27])=[CH:21][CH:22]=2)[C:17]([NH:28][CH2:29][C:30](=[O:36])[NH:31][CH:32]2[CH2:33][N:34]([CH:42]3[CH2:43][CH2:44][CH:39]([C:37]#[N:38])[CH2:40][CH2:41]3)[CH2:35]2)=[N:16]1)=[O:14])([CH3:11])([CH3:9])[CH3:10]

Participants

3

Reactant 2

HCID 122356394-Oxocyclohexane-1-carbonitrileHCID 1317305553-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt

Product 1

HCID 54755925HCID 54755925, compound

Procedure

The title compound was prepared as a white solid from reaction of 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt (as prepared in Example 81, Step D) and 4-cyano-cyclohexanone using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-bfdc994db5344e71adf2d4f4129da6c7
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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